BIOL 4312: Genetics

Goals of this course

Students should understand basic principles and mechanisms of inheritance and variation, including cytological, organismal, developmental, and population genetics; mechanisms of evolution; and the genetic problems of humans.

Schedule

Lecture: 11:45AM-12:50PM MW, Sci 1020
Lab002: 12:00PM-3:00PM T, Sci 3160
Lab003: 3:00PM-6:00PM T, Sci 3160

Office hours: 9:00-11:00 Monday and Tuesday, or by appointment, Sci 2135

Textbook

Klug and Cummings, Concepts of Genetics, 9th Edition
(7th or 8th edition are also acceptable)

Tentative class schedule

(Subject to revision throughout the term)

DateTopicAssignments

21 Jan

Introduction

9th, 8th ed.: Chapter 1, problems 4, 5, 6, 8
7th ed.: Chapter 1, problems 5, 6. Also: a) What is an allele? b) Why was it difficult for soome scientists to accept that DNA was the carrier of genetic information?

26 Jan

NO CLASS

Read Chapter 3.8-3.9 (all editions) for lab next week

28 Jan

Cytology and TH Morgan

Chapter 2
9th ed.: 1, 2, 3, 5, 6, 11, 12, 16, 14, 20
8th ed.: 1, 2, 3, 5, 6, 11, 12, 16, 9, 20
7th ed.: 1, 2, 3, 5, 6, 11, 12, 16, 14, 18

2 Feb

Mitosis and meiosis

Chapter 2

4 Feb

Mendelian inheritance

Chapter 3
problems 1, 2, 3, 6, 7, 8, 9, 10, 11, 15, 21, 22, 23 24, 26, 33, 36 (all editions)

9 Feb

Mendelian inheritance: trihybrid crosses and pedigrees

11 Feb

Practice Exam!

Chapter 1, 2, 3

16 Feb

Extensions of Mendelian genetics

Chapter 4
8th, 9th ed. problems: 1-8, 10, 14, 17, 21, 32, 34, 35
7th ed. problems: 1-8, 10, 14, 17, 21, 31, 33, 34

18 Feb

More extensions

23 Feb

Linkage

25 Feb

Exam I

Chapters 1-4

2 Mar

Chromosome mapping in eukaryotes

9th, 8th ed: Chapter 5, problems: 1, 4, 5, 8, 10, 11, 13, 14, 16, 17, 18, 24, 26, 27
7th ed: Chapter 6, problems: 1, 4, 5, 8, 10, 11, 13, 14, 16, 17, 18, 24, 26, 27

4 Mar

Chromosome mapping in eukaryotes - in-class problems

Chapter 5

9 Mar

Sex determination and sex chromosomes

Chapter 7

11 Mar

(cancelled by blizzard + spring fever)

16 Mar

SPRING BREAK

18 Mar

SPRING BREAK

23 Mar

Sex determination and sex chromosomes

9th ed: Chapter 7, problems: 6, 13, 17, 18, 21,22, 23, 25,26, 32, 34, 35
8th ed: Chapter 7, problems: 6, 11, 15, 17, 19, 20, 21, 23, 24, 29, 31, 32
7th ed: Chapter 7, problems: 3, 6, 9, 10, 21, 23 (note: major changes in problem sets from the 7th edition. See more recent copy to get the missing ones.)

25 Mar

NO CLASS

start reading Chapter 8!

30 Mar

Linkage and sex problems

Chapter 5, 7

1 Apr

Exam II

6 Apr

Chromosomal variations

Chapter 8: problems: 1, 2, 3, 4, 5, 9, 10, 13, 14, 15, 17, 23, 31

8 Apr

Chromosomal variations 2

Chapter 8

13 Apr

Chromosomal variations 3

Chapter 8

15 Apr

Extrachromosomal inheritance

Chapter 9

20 Apr

More extrachromosomal inheritance

22 Apr

NO CLASS

27 Apr

practice questions

Chapter 9: problems: 3, 6, 7, 9, 10, 11, 12, 17, 20

29 Apr

Exam III

4 May

Developmental genetics of model organisms

Chapter 19

6 May

Developmental genetics of model organisms

Chapter 19

13 May

FINAL EXAM: 4:00-6:00


Final Lab results

In the cross of wmf female flies with wildtype males, we observed:

wildtype females930
wmf males679
Anomalous results (not used in further crosses)
wmf females66
wildtype males180

In the cross of wildtype female flies with wmf males, we observed:

wildtype females892
wildtype males829

In the test cross of female heterozygotes with wmf males, we observed:

malefemaletotal
+++7938701663
wmf5386791217
w++372390762
+mf241279520
++f172230402
wm+334338672
+m+183142325
w+f295483
266229825644

Good work everyone — these look like good numbers. Now analyze them!


Grading

50% of your grade will come from three in-class exams. Four exams will be given (including the final exam), and your lowest score will be dropped.

10% of your grade will come from pop quizzes. Don't ask me for hints about when they'll be given — the whole point is that you should be prepared and on top of the course work throughout the term. There will be no make-ups on quizzes.

40% of your grade will come from lab work. You will be evaluated on attendance, routine worksheets, and most importantly, a substantial report on the analysis of a mapping cross.

Attendance

I will not be tracking lecture attendance at all; it is your responsibility to keep up with the material. Genetics is not a forgiving subject, and everything will build on prior lectures. Falling behind can make subsequent work much, much harder than it should be. Show up and pay attention!

Makeup Exams

There are no makeups for quizzes. If you miss a regular exam, contact me immediately: if you have a legitimate excuse, you will be permitted to take the exam at a time and date I will set. If you don't contact me within two days of the exam, you will get a 0. (Note that you do get to drop your lowest score.)

Disability Accommodations

It is University policy to provide reasonable accommodations to students with disabilities. This publication/material is available in alternative formats to persons with disabilities upon request. Please contact the instructor or the Disability Services office, 589-6178, Room 362 Briggs Library to discuss accommodation needs.

Academic Dishonesty

Academic dishonesty in any portion of the academic work for a course shall be grounds for awarding a grade of F or N for the entire course. You are often encouraged to study in groups, but the final product must be your own creation (e.g. you may not copy from each other). Plagiarism is copying materials from existing sources without crediting the sources, and is not accepted. Paraphrasing is changing a few words in a sentence to make it sound like your own but stealing the structure of the sentence, paragraph and document of someone else. Plagiarism and paraphrasing are cheating. Cutting, pasting and modifying from web sites is cheating. In summary, you need to develop and formulate your own thoughts with the information you have obtained.